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MRI Detects Brain Iron Deposition in Thalassaemia Patients Using Quantitative Susceptibility Mapping and T2*-Weighted Mapping

Received: 6 December 2016     Published: 7 December 2016
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Abstract

Purpose: MRI(Magnetic Resonance Imaging) estimates of brain iron deposition in thalassaemia patient using quantitative susceptibility mapping (QSM) and T2*-weighted methods. And to compare the two methods, if they have feasibility. Thirty-three thalassaemia patients underwent gradient echo sequence on the MR (Magnetic Resonance) scanner with whole-brain coverage to obtain the image data. Then to process the images and calculate the brain iron content using QSM (Quantitative Susceptibility Mapping) and T2*-weighted methods. Both images using QSM and T2* methods can clearly see the distribution of iron in the brain. But T2*-weighted method is less sensitivity for the detection of brain iron content, and only QSM method can quantify the iron content quickly and accurately. The tissue iron can affect the value of T2*, so T2*-weighted method can only detect the distribution of iron content. While the application of magnetic sensitive quantitative imaging can be very effective in routine non-invasive assessment of tissue components, especially iron, that is very important for the assessment of thalassemia patients.

Published in Science Discovery (Volume 4, Issue 6)
DOI 10.11648/j.sd.20160406.20
Page(s) 405-409
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Quantitative Susceptibility Mapping, T2*-Weighted Mapping, Magnetic Resonance Imaging, Thalassaemia, Iron Concentration

References
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  • APA Style

    Guo Hongyu, Wang Yanjun, Huang Ping, Guo Hua. (2016). MRI Detects Brain Iron Deposition in Thalassaemia Patients Using Quantitative Susceptibility Mapping and T2*-Weighted Mapping. Science Discovery, 4(6), 405-409. https://doi.org/10.11648/j.sd.20160406.20

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    ACS Style

    Guo Hongyu; Wang Yanjun; Huang Ping; Guo Hua. MRI Detects Brain Iron Deposition in Thalassaemia Patients Using Quantitative Susceptibility Mapping and T2*-Weighted Mapping. Sci. Discov. 2016, 4(6), 405-409. doi: 10.11648/j.sd.20160406.20

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    AMA Style

    Guo Hongyu, Wang Yanjun, Huang Ping, Guo Hua. MRI Detects Brain Iron Deposition in Thalassaemia Patients Using Quantitative Susceptibility Mapping and T2*-Weighted Mapping. Sci Discov. 2016;4(6):405-409. doi: 10.11648/j.sd.20160406.20

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  • @article{10.11648/j.sd.20160406.20,
      author = {Guo Hongyu and Wang Yanjun and Huang Ping and Guo Hua},
      title = {MRI Detects Brain Iron Deposition in Thalassaemia Patients Using Quantitative Susceptibility Mapping and T2*-Weighted Mapping},
      journal = {Science Discovery},
      volume = {4},
      number = {6},
      pages = {405-409},
      doi = {10.11648/j.sd.20160406.20},
      url = {https://doi.org/10.11648/j.sd.20160406.20},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20160406.20},
      abstract = {Purpose: MRI(Magnetic Resonance Imaging) estimates of brain iron deposition in thalassaemia patient using quantitative susceptibility mapping (QSM) and T2*-weighted methods. And to compare the two methods, if they have feasibility. Thirty-three thalassaemia patients underwent gradient echo sequence on the MR (Magnetic Resonance) scanner with whole-brain coverage to obtain the image data. Then to process the images and calculate the brain iron content using QSM (Quantitative Susceptibility Mapping) and T2*-weighted methods. Both images using QSM and T2* methods can clearly see the distribution of iron in the brain. But T2*-weighted method is less sensitivity for the detection of brain iron content, and only QSM method can quantify the iron content quickly and accurately. The tissue iron can affect the value of T2*, so T2*-weighted method can only detect the distribution of iron content. While the application of magnetic sensitive quantitative imaging can be very effective in routine non-invasive assessment of tissue components, especially iron, that is very important for the assessment of thalassemia patients.},
     year = {2016}
    }
    

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  • TY  - JOUR
    T1  - MRI Detects Brain Iron Deposition in Thalassaemia Patients Using Quantitative Susceptibility Mapping and T2*-Weighted Mapping
    AU  - Guo Hongyu
    AU  - Wang Yanjun
    AU  - Huang Ping
    AU  - Guo Hua
    Y1  - 2016/12/07
    PY  - 2016
    N1  - https://doi.org/10.11648/j.sd.20160406.20
    DO  - 10.11648/j.sd.20160406.20
    T2  - Science Discovery
    JF  - Science Discovery
    JO  - Science Discovery
    SP  - 405
    EP  - 409
    PB  - Science Publishing Group
    SN  - 2331-0650
    UR  - https://doi.org/10.11648/j.sd.20160406.20
    AB  - Purpose: MRI(Magnetic Resonance Imaging) estimates of brain iron deposition in thalassaemia patient using quantitative susceptibility mapping (QSM) and T2*-weighted methods. And to compare the two methods, if they have feasibility. Thirty-three thalassaemia patients underwent gradient echo sequence on the MR (Magnetic Resonance) scanner with whole-brain coverage to obtain the image data. Then to process the images and calculate the brain iron content using QSM (Quantitative Susceptibility Mapping) and T2*-weighted methods. Both images using QSM and T2* methods can clearly see the distribution of iron in the brain. But T2*-weighted method is less sensitivity for the detection of brain iron content, and only QSM method can quantify the iron content quickly and accurately. The tissue iron can affect the value of T2*, so T2*-weighted method can only detect the distribution of iron content. While the application of magnetic sensitive quantitative imaging can be very effective in routine non-invasive assessment of tissue components, especially iron, that is very important for the assessment of thalassemia patients.
    VL  - 4
    IS  - 6
    ER  - 

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Author Information
  • Biomedical Engineering, Shenyang University of Technology, Shenyang, China

  • Electrical Engineering, Shenyang University of Technology, Shenyang, China

  • Biomedical Engineering, Shenyang University of Technology, Shenyang, China

  • Center for Biomedical Imaging Research, Tsinghua University, Beijing, China

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